Sunday , June 24 2018

Neural and Hybrid Modelling of Biotechnological Process

Elena CHORUKOVA, Ivan SIMEONOV
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences
Acad. G. Bonchev St., Bl. 26, 1113 Sofia, Bulgaria

Abstract: The paper deals with neural and hybrid modelling of the three main types of biotechnological processes – batch and fed-batch processes for the enzyme superoxide dismutase (SOD) production and continuous process of anaerobic digestion (AD) of organic wastes. Neural models for batch SOD production with and without dissolved oxygen regulation have been developed. A hybrid model for fed-batch process for SOD production and neural model for continuous AD process have been developed as well. The most appropriate network architecture in all cases is with one hidden layer with hyperbolic tangent activation function and output layer with linear activation function.

Keywords: SOD production, anaerobic digestion, laboratory experiments, neural models, hybrid models.

Elena Chorukova received her MSc degree in Bioengineering from the Technical University of Sofia, Bulgaria, in 1994. Since 2000 she has been a Research Associate at the Bulgarian Academy of Sciences, in the research group “Mathematical Modeling and Computer Science” of the Stephan Angeloff Institute of Microbiology. She is the author/co-author of about 30 scientific papers published in international journals and conference proceedings.

Ivan Simeonov received his MSc and PhD degrees in Control Engineering from the Technical University of Sofia, Bulgaria, in 1971 and 1981, respectively. Since 1986 he has been a Senior Research Associate with the Bulgarian Academy of Sciences, where he is presently the Head of the research group “Mathematical Modeling and Computer Science” at the Institute of Microbiology. He has been an Associate Professor at the Technical University of Sofia (1988-1999), Technical University of Gabrovo (2000-2005) and New Bulgarian University (since 2005). He is the author/co-author of over 160 scientific papers published in international journals and conference proceedings.

>>Full text
CITE THIS PAPER AS:
Elena CHORUKOVA, Ivan SIMEONOV, Neural and Hybrid Modelling of Biotechnological Process, Studies in Informatics and Control, ISSN 1220-1766, vol. 17 (3), pp. 305-314, 2008.