The paper characterizes Technology Transfer (TT), having critically examined important overall issues of TT, challenges of TT in Europe, methodologies of TT adopted in CIME R&D ESPRIT projects and the experience of AITIME project. It identifies problems and barriers that ought to be overcome by further research and demonstrates how new approaches of TT can be utilized to provide wider-scope solutions. An overview of the recent trends of TT in the context of European Projects is also presented. The performance and efficiency of the contemporary TT practices are further examined. Our scope is to better understand the potential advantages and limitations associated with these TT approaches and to show how new TT concepts can help utilize the CIME practices and conduct business in a more effective way. A conceptual model of TT functions and operations named the T-cube (Technology Transfer Tree) is proposed.